URACIL OXIDASE AND THE ISOLATION OF BARBITURIC ACID FROM URACIL OXIDATION
نویسندگان
چکیده
منابع مشابه
Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes.
Early stud& with pyrimidines administered t.o animals established the fact that, these compounds arc metabolized (3, 4). Present concepts of the pathways of pyrimidine metabolism stem largely from the work of Cerecedo (4), in which he measured the changes in the urinary excretion of urea after feeding pyrimidines and related subst.ances. On the basis of these studies, he proposed an init.ial ox...
متن کاملUracil photoproducts from uracil irradiated in ice.
Two new products were isolated from uracil irradiated with ultraviolet light in frozen aqueous solution. As judged by mass, nuclear magnetic resonance, and ultraviolet and infrared spectra, one is a photopolymer, U(3) and the structure of the other is probably 6-4'-[ pyrimidin-2'-one]-uracil. Formations of these products between pyrimidine bases are apparently common photoreactions, and may be ...
متن کاملHerpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.
We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time the induction of the enzyme is a maximum. The enzyme has been shown to be distinct from the host enzyme, isolated from HeLa cells, by its lack of sensitivity to a monoclonal antibody to human uracil-DNA glycosylase. Furthermore, several ura...
متن کاملPrecluding uracil from DNA.
Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.
متن کاملA structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs
The uracil DNA glycosylase superfamily consists of several distinct families. Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to exhibit glycosylase activity on three mismatched base pairs, T/U, G/U and C/U. Family 1 uracil N-glycosylase (UNG) from E. coli is an extremely efficient enzyme that can remove uracil from any uracil-containing base pairs includi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55833-6